Endocrine Abstracts

Introduction: We conducted a prospective study to compare the efficacy of continuous glucose monitoring (CGM) devices versus capillary blood glucose (CBG) in the glycemic control of inpatient type 2 diabetes on intensive insulin therapy. The use of CGM was associated with improved glycemic control, including an increased time in range (TIR) and reduced hyperglycemic events, being safe concerning hypoglycemias. The present study is the cost-effectiveness analysis associated wit...

Introduction: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as a promising class of medications, demonstrating a significant reduction in the risk of cardiovascular events. An associated consequence of SGLT2i is an increase in hematocrit levels, with cardiovascular outcome trials revealing frequent hematocrit mean elevations varying from +2.3% to 3.5%. This rise in hematocrit introduces a potential dilemma when evaluating the risk-benefit profile of SGLT2i i...

Introduction: The immune checkpoint inhibitors (ICI) are increasingly being used in the treatment of several malignancies. ICI are monoclonal antibodies that inhibit immune checkpoints, thus stimulating the action of the immune cells to attack the tumour cells. The overstimulation of the immune system can lead to several endocrinopathies, such as autoimmune diabetes, known as ICI-associated diabetes mellitus (ICIDM).Case Report: In September 2023, a 62-y...

Introduction: Adrenal incidentalomas are tumors incidentally discovered on imaging tests. Regarding functionality, although 75% of adrenal incidentalomas are non-functioning cortical adenomas (NFAA), there is a subset of adrenal incidentalomas associated with important clinical consequences: adrenocortical cancer (ACC), pheochromocytoma (PHEO, together with paraganglioma (PGL) referred as PPGL), primary aldosteronism (PA), mild-autonomous cortisol secretion (MACS) and Cushing ...

Introduction: Terlipressin is a non-selective vasopressin analogue used in patients with decompensated cirrhosis, gastrointestinal haemorrhage or hepatorenal syndrome. It directly binds to V1 receptors improving circulatory volume by causing splanchnic vasoconstriction and portal hypertension inhibition, and has a full V2 receptor agonism in the collecting duct. In consequence, it increases reabsorption of water and can lead to a decrease in plasma osmolality and hyponatremia....

Introduction: Current guidelines propose temozolomide (TMZ) as the first-line chemotherapy for aggressive pituitary neuroendocrine tumors (PitNETs), but no clinical trials have been conducted and clinical experience in this context is limited.Patients and methods: A retrospective study of patients with aggressive pitNETs treated with TMZ was conducted by the members of the Neuroendocrinology Working Area of the Spanish Society of Endocrinology and Nutrit...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...

Background: Bariatric surgery has been associated with a decrease in multiple obesity-related comorbidities including obstructive sleep apnoea syndrome (OSA). This study aims to access the OSA evolution in obese patients who underwent bariatric surgery.Methods: Retrospective longitudinal study of a population of obese patients who underwent bariatric surgery between January/2010 and July/2014 in our centre. Only patients who have undergone polysomnograph...

The relationship between periodontitis and diabetes mellitus (DM) is widely accepted. Several studies identified a greater incidence of periodontitis and an increase of its severity in diabetic patients, approximately threefold.In this study, we want to investigate the influence of type 2 DM (T2DM) in the development of periodontitis.Single center, randomized trial with 90 patients T2DM. Exclusion criteria: chronic renal disease (G...